Collagen/ORC has been proven to reduce levels of proteases such as MMPs and Elastase.
This may restore the balance of the wound microenvironment, promoting granulation tissue and helping the wound close.5
By reducing both MMP and Elastase activity the wound surface area has been shown to reduce. Collagen alone has been shown to be less effective at reducing protease activity (see graph 2).
COLLAGEN/ORC has the ability to reduce wound surface area11
(see graph 1)
The on the role of Proteases in wound healing
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1. Lazaro-Martinez et al. Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers. F.R. Circ. Esp.2007, 82(1), 27-31
2. Veves A et al. A randomized , controlled trial of Collagen/ORC vs standard treatments in the management of diabetic foot ulcers. Arch Surg 2002;137:822-827
3. Snyder. Sequential therapies and advanced wound care products as a standard practice in the home care setting. Home health abstract for SAWC, San Diego, April 2008 (presentation at the J&J satellite symposium)
4. Ghatenekar O. Willis. M. Persson U. Health Economics. ‘Cost effectiveness of treating deep diabetic foot ulcers with collagen/ORC in four European countries’. J Wound Care, Vol 11, No2. Feb 2002
5. Cullen B, Smith R, McCulloch E, Silcock D, Morrison L. Mechanism of action of Collagen/ORC, a protease modulating matrix for treatment of diabetic foot ulcers. Wound Rep Regen 2002;10:16-25.
11. Cullen, B., Kemp, L., Essler, L. Rebalancing wound biochemistry improves healing: a clinical study examining effect of PROMOGRAN. Wound Repair Regen. 2004 12(2) A4
12. Cullen et al. A comparison of collagen containing dressings to modify the chronic wound environment. EWMA 2007
13. Cullen, B., Boyle, C., Webb, Y. Modulation of the chronic wound environment; an in vitro evaluation of advanced wound therapies. SAWC, Tampa FL, 2007.