Letís Heal™ is the result of 75 years experience in developing our products to help you test, protect, promote and comfort the wound towards healing.



For more information on the potential clinical value of a protease test, click one of the links below:

Defining EPA (elevated protease activity) and why a test able to detect EPA is needed and clinically relevant:
Type Year of
Author Title
Poster 2013 Nherera, L.,
et al.
Quantifying the economic value of diagnostics in wound care in the UK
Clinical Poster 2013 Gibson, M.,
et al.
The benefits of testing all wounds, whether assessed as healing or non-healing
Clinical Poster 2013 Duteille, F. Evaluation of the use of a point of care test for proteases to identify patients with increased risk of skin graft failure
Clinical Poster 2013 Anichini, R.,
et al.
Detecting and treating elevated protease activity (EPA) in chronic diabetic wounds
Clinical Poster 2012 Cullen, B.,
et al.
Targeted use of collagen/ORC improves clinical outcome
Clinical Poster 2011 Serena, T.,
et al.
Protease activity levels associated with healing status of chronic wounds
Clinical Poster 2011 Snyder, R.,
et al.
The importance of proteases in wound healing and wound assessment
Consensus documents:
Type Year of publication Title
Consensus document 2012 Die Rolle eines Proteasen Schnelltests in der Wunddiagnostik (DACH - Germany, Austria, Switzerland)
Consensus document 2011 The role of a point-of-care protease activity diagnostic test in Canadian clinical practice (Canada)
Consensus document 2011 Significato e valutazione delle proteasi nel processo di riparazione tessutale (Italy)
Consensus document 2011 Using a diagnostic tool to identify elevated protease activity levels in chronic and stalled wounds: a consensus panel discussion (US)
Consensus document 2011 Protease diagnostic in wound care: round-table meeting (UK)
Consensus document 2011 The role of proteases in wound diagnostics (International)
Diagnostics in wound care:
Type Year of publication Title
Symposium 2012 The arrival of wound diagnostics
Symposium 2011 You can't manage what you can't measure
Symposium 2010 Diagnostics masterclass
Consensus document 2008 World Union of Wounds Healing Societies consensus document
Understanding proteases and healing in wound care:
Type Year of publication Title
Article 2013 EPA made easy

Please refer in full to the Instructions for use leaflet provided in the product packaging, specific to your region.

Systagenix is not responsible for the content of external websites.

The product information on this page is not intended for, or to be used by health care professionals or users in the United States



1. Serena T. et al. Protease activity levels associated with healing status of chronic wounds.Poster, Wounds UK 2011.

2. Snyder R. et al. A survey: The importance of proteases in wound healing and wound assessment. Poster, Wounds UK 2011.

3. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.

4. Gordois A, Scuffham P, Shearer A, Oglesby A, Tobian JA. The healthcare costs of diabetic peripheral neuropathy in the US. Diabetes Care. 2003;26(6):1790–1795.

5. Shearer A, Scuffham P, Gordois A, Oglesby A. Predicted costs and outcomes from reduced vibration detection in people with diabetes in the U.S. Diabetes Care. 2003;26(8):2305–2310.

6. Instructions for Use 2011.

7. Lazarus GS, Cooper DM, Knighton DR, et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol. 1994;130(4):489-493.

8. Consensus on Use of a Diagnostic Tool in Stalled Wounds to Identify Excess Protease Levels. The Protease Diagnostic Consensus Panel. Ostomy Wound Management. Ostomy Wound Management 2011;57(12): 36-48.